Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 3/20 | 0.45 |
| ▸ | CACNB4 | O00305 | 3/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.45 |
| ▸ | CACNG3 | O60359 | 3/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.45 |
| ▸ | CACNB3 | P54284 | 3/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.45 |
| ▸ | CACNG7 | P62955 | 3/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.45 |
| ▸ | CACNG1 | Q06432 | 3/20 | 0.45 |
| ▸ | CACNB2 | Q08289 | 3/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.45 |
| ▸ | CACNA1E | Q15878 | 3/20 | 0.45 |
| ▸ | CACNA2D4 | Q7Z3S7 | 3/20 | 0.45 |
| ▸ | CACNA2D3 | Q8IZS8 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20252778 | 0.90 | CACNB4 (0.43) | NAAACACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL15830030 | 0.83 | NAAA (0.48) | NAAACACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL18672932 | 0.83 | TLR9 (0.43) | TDO2TLR8TLR7CYP2D6HRH3 | |
| SCHEMBL20890032 | 0.82 | LOX (0.45) | TLR8TLR7ACACB | |
| SCHEMBL19473347 | 0.80 | PRMT5 (0.49) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL16217407 | 0.80 | NAAA (0.45) | NAAACACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL17308310 | 0.80 | CACNB4 (0.48) | NAAACACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL20252757 | 0.80 | LOX (0.50) | ACACB | |
| SCHEMBL19633496 | 0.79 | GPR119 (0.49) | NAAACACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL19473336 | 0.78 | TLR8 (0.46) | GPR119TLR8TLR7HRH3ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10980794-B2 | PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2021-04-20 | — | — | US | disclosed |
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20170334861-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | PRMT5, PRMT1, PRMT3 | NAAA 2699/4885CACNB4 4199/4885CACNA1A 3247/4885 |
| US-20170334861-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT3 | NAAA 2699/4885CACNB4 4199/4885CACNA1A 3247/4885 |
| US-10980794-B2 | PRMT5 inhibitors and uses thereof | PRMT5, PRMT1, PRMT6 | NAAA 3216/4885CACNB4 4513/4885CACNA1A 3951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.