SCHEMBL19634405

SCHEMBL19634405

CC(C)C(=O)NCc1ccc(C(=O)NCCN2CCSCC2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 3/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
LMNA P02545 1/20 0.47
POLB P06746 2/20 0.46
ALDH1A1 P00352 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
GLA P06280 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
HTR1A P08908 1/20 0.44
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
KCNH2 Q12809 1/20 0.44
CD274 Q9NZQ7 1/20 0.44
SLC6A2 P23975 1/20 0.44
SLC6A4 P31645 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23471332 0.87 HDAC6 (0.52) NAMPTHDAC2HDAC8HDAC6NPSR1
SCHEMBL19634685 0.86 CD274 (0.62) NAMPTPOLBALDH1A1HTR1AMAOA
SCHEMBL19634397 0.86 HASPIN (0.55) NAMPTHDAC2HDAC8HDAC6NPSR1
SCHEMBL19634442 0.84 HDAC6 (0.55) NAMPTHDAC2HDAC8HDAC6NPSR1
SCHEMBL19634690 0.80 ALDH1A1 (0.52) HDAC2HDAC8HDAC6NPSR1POLB
SCHEMBL13115955 0.79 CYP2C19 (0.45) POLBALDH1A1CYP1A2
SCHEMBL19634414 0.79 HPGD (0.55) NAMPTALDH1A1L3MBTL1HTR1A
SCHEMBL19634439 0.75 NPSR1 (0.67) NAMPTHDAC2HDAC8HDAC6NPSR1
SCHEMBL19634416 0.74 HDAC6 (0.69) NAMPTHDAC2HDAC8HDAC6NPSR1
SCHEMBL19634451 0.74 NPSR1 (0.65) NAMPTHDAC2HDAC8HDAC6NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017200984-A1 NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF S&T GLOBAL INC. (US) 2017-11-23 WO disclosed