Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5109753 | 0.86 | LOXL2 (0.54) | ALDH1A1LMNAMAPK1TMEM97SIGMAR1 | |
| SCHEMBL19634425 | 0.86 | ALDH1A1 (0.73) | ALDH1A1LMNASLC22A2SLC22A1TSHR | |
| SCHEMBL23471351 | 0.84 | ALDH1A1 (0.55) | ALDH1A1LMNASLC22A2SLC22A1TSHR | |
| SCHEMBL27208048 | 0.83 | ALDH1A1 (0.69) | ALDH1A1LMNASLC22A2SLC22A1TSHR | |
| SCHEMBL19354778 | 0.82 | NPC1 (0.59) | ALDH1A1LMNASLC22A2SLC22A1TSHR | |
| SCHEMBL19634803 | 0.81 | TDP1 (0.50) | ALDH1A1LMNASLC22A2SLC22A1TSHR | |
| SCHEMBL14081049 | 0.81 | LOXL2 (0.61) | CYP2C19KMT2AMEN1LOXL2SMN1; SMN2 | |
| SCHEMBL172995 | 0.80 | CFD (0.56) | ALDH1A1MAPK1TMEM97SIGMAR1SMN1; SMN2 | |
| SCHEMBL5095811 | 0.80 | CFD (0.57) | ALDH1A1HPGDKDM4ELOXL2SMN1; SMN2 | |
| SCHEMBL1854346 | 0.80 | SMN1; SMN2 (0.66) | LMNALOXL2SMN1; SMN2CFDCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017200984-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. (US) | 2017-11-23 | — | — | WO | disclosed |