Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1968753 | 0.81 | TRPM8 (0.46) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3235765 | 0.79 | CACNA1H (0.51) | MAPTLMNATP53THRBCACNA1H | |
| SCHEMBL302889 | 0.73 | LMNA (0.54) | MAPTLMNACACNA1HL3MBTL1ALDH1A1 | |
| SCHEMBL3279971 | 0.72 | MAPT (0.61) | MAPTLMNATP53THRBCACNA1H | |
| SCHEMBL1965535 | 0.69 | MAPT (0.57) | MAPTLMNATP53THRBCACNA1H | |
| SCHEMBL1966566 | 0.69 | LMNA (0.44) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3377793 | 0.69 | MAPT (0.64) | MAPTLMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL3278531 | 0.69 | HTT (0.57) | MAPTLMNATP53THRBCACNA1H | |
| SCHEMBL1967123 | 0.68 | LMNA (0.68) | MAPTLMNAL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL301695 | 0.68 | GAA (0.76) | MAPTLMNACACNA1HL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | disclosed |