Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHAT | P28329 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886 | 0.88 | — | — | |
| SCHEMBL724748 | 0.72 | ALDH1A1 (0.50) | ALDH1A1LMNAL3MBTL1TDP1MAPK1 | |
| SCHEMBL1302 | 0.68 | ALDH1A1 (0.53) | ALDH1A1TSHRMAOBCYP2A6LMNA | |
| SCHEMBL2186055 | 0.67 | TP53 (0.40) | ALDH1A1MAOBTDP1NFE2L2CYP19A1 | |
| SCHEMBL29111027 | 0.67 | ALDH1A1 (0.53) | AKR1C3ALDH1A1TSHRMAOBCYP2A6 | |
| SCHEMBL9368926 | 0.67 | CALM1 (0.57) | MAOBLMNAL3MBTL1 | |
| SCHEMBL723501 | 0.67 | LTA4H (0.57) | ALDH1A1TSHRLMNAL3MBTL1TRPA1 | |
| SCHEMBL1005178 | 0.67 | MAOA (0.44) | ALDH1A1MAOAALOX5 | |
| SCHEMBL22711559 | 0.65 | ALDH1A1 (0.50) | ALDH1A1TSHRMAOBCYP2A6LMNA | |
| SCHEMBL29124096 | 0.65 | ALDH1A1 (0.50) | ALDH1A1TSHRMAOBCYP2A6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115626923-B | KRAS G12C inhibitors and methods of use thereof | 美国安进公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-112279808-B | Cystic fibrosis transmembrane conductance regulator modulators | 弗特克斯药品有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-112250627-B | Cystic fibrosis transmembrane conductance regulator modulators | 弗特克斯药品有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116621833-A | KRAS G12C inhibitors and methods of use thereof | 美国安进公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-116606261-A | KRAS G12C inhibitors and methods of use thereof | 美国安进公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-110003217-B | Compositions useful for treating disorders associated with KIT | 缆图药品公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-112279808-A | Cystic fibrosis transmembrane transduction modulator modulators | 弗特克斯药品有限公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-112250627-A | Cystic fibrosis transmembrane transduction modulator modulators | 弗特克斯药品有限公司 | 2021-01-22 | — | — | CN | disclosed |
| CN-107690281-B | Cystic fibrosis transmembrane transduction modulator modulators | 弗特克斯药品有限公司 | 2020-11-17 | — | — | CN | disclosed |
| US-10577460-B2 | Method for producing polyester | NIPPON SODA CO., LTD. (JP) | 2020-03-03 | — | — | US | disclosed |
| CN-110366550-A | Benzoisothiazole, isothiazolo [3,4-b ] pyridine, quinazoline, phthalazine, pyrido [2,3-d ] pyridazine and pyrido [2,3-d ] pyrimidine derivatives as KRAS G12C inhibitors for the treatment of lung, pancreatic or colorectal cancer | 美国安进公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-110003217-A | It can be used for treating the composition of illness relevant to KIT | 蓝图药品公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-107108871-B | The manufacturing method of polyester | 日本曹达株式会社 | 2019-04-30 | — | — | CN | disclosed |
| CN-105658652-B | Compositions useful for treating disorders associated with KIT | 蓝图药品公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-107690281-A | Cystic fibrosis transmembrane transduction modulator modulators | 弗特克斯药品有限公司 | 2018-02-13 | — | — | CN | disclosed |
| EP-3248998-A1 | METHOD FOR PRODUCING POLYESTER | Nippon Soda Co., Ltd. (JP) | 2017-11-29 | — | — | EP | disclosed |
| CN-107108871-A | The manufacture method of polyester | 日本曹达株式会社 | 2017-08-29 | — | — | CN | disclosed |
| CN-106999479-A | It can be used as the heteroaryl compound of SUMO activating enzyme inhibitors | 米伦纽姆医药公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-101970437-B | Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals | SANOFI AVENTIS | 2013-04-03 | — | — | CN | disclosed |