Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.57 |
| ▸ | WDR5 | P61964 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067414 | 0.83 | MAPT (0.69) | MYCWDR5MAPTALDH1A1KDM4E | |
| SCHEMBL19650376 | 0.83 | MYC (0.60) | MYCWDR5MAPTALDH1A1KDM4E | |
| SCHEMBL20703602 | 0.83 | HSD17B10 (0.54) | MYCWDR5MAPTALDH1A1KDM4E | |
| SCHEMBL7050538 | 0.83 | MAPT (0.59) | MYCWDR5MAPTALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9548025 | 0.81 | KDM4E (0.67) | MYCWDR5MAPTALDH1A1KDM4E | |
| SCHEMBL558439 | 0.81 | ALDH1A1 (0.68) | MYCWDR5MAPTALDH1A1KDM4E | |
| SCHEMBL201690 | 0.81 | ALDH1A1 (0.68) | MYCWDR5MAPTALDH1A1KDM4E | |
| SCHEMBL19638014 | 0.80 | MYC (0.57) | MYCWDR5MAPTALDH1A1KDM4E | |
| SCHEMBL16669665 | 0.78 | ALDH1A1 (0.75) | MYCWDR5MAPTALDH1A1KDM4E | |
| SCHEMBL20767251 | 0.78 | ALDH1A1 (0.67) | MYCWDR5MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207445-B | Adenosine A3Modulators of receptors | 帕罗生物制药有限公司 | 2021-03-16 | — | — | CN | disclosed |
| US-10913714-B2 | Pyrrole sulfonyl derivative, preparation method and medical use thereof | JIANGSU CAREPHAR PHARMACEUTICAL CO., LTD (CN) | 2021-02-09 | — | — | US | disclosed |
| CN-107207432-B | Pyrroles's sulphonyl analog derivative, preparation method and its application in medicine | 江苏柯菲平医药股份有限公司 | 2019-09-17 | — | — | CN | disclosed |
| EP-3248963-B1 | PYRROLE SULFONYL DERIVATIVE, AND PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU CAREPHAR PHARMACEUTICAL CO LTD (CN) | 2019-07-17 | — | — | EP | disclosed |
| EP-3248964-B1 | THIAZOLE MODULATORS OF A3 ADENOSINE RECEPTORS | PALOBIOFARMA SL (ES) | 2019-07-17 | — | — | EP | disclosed |
| US-10238637-B2 | Modulators of the adenosine A3 receptors | PALOBIOFARMA, S.L. (ES) | 2019-03-26 | — | — | US | disclosed |
| US-20180263963-A1 | MODULATORS OF THE ADENOSINE A3 RECEPTORS | PALOBIOFARMA, S.L. (ES) | 2018-09-20 | — | — | US | disclosed |
| US-20180009749-A1 | Pyrrole Sulfonyl Derivative, Preparation Method and Medical Use thereof | JIANGSU CAREFREE PHARMACEUTICAL CO., LTD (CN) | 2018-01-11 | — | — | US | disclosed |
| EP-3248963-A1 | PYRROLE SULFONYL DERIVATIVE, AND PREPARATION METHOD AND MEDICAL USE THEREOF | Jiangsu Carephar Pharmaceutical Co., Ltd (CN) | 2017-11-29 | — | — | EP | disclosed |
| EP-3248964-A1 | THIAZOLE MODULATORS OF A3 ADENOSINE RECEPTORS | PALOBIOFARMA S.L. (ES) | 2017-11-29 | — | — | EP | disclosed |
| CN-107207432-A | Pyrroles's sulphonyl analog derivative, its preparation method and its in application pharmaceutically | 江苏柯菲平医药股份有限公司 | 2017-09-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180263963-A1 | MODULATORS OF THE ADENOSINE A3 RECEPTORS | ADORA3, ADORA2A, ADORA1 | MYC 4788/4885WDR5 3585/4885MAPT 3832/4885 |
| US-20180009749-A1 | Pyrrole Sulfonyl Derivative, Preparation Method and Medical Use thereof | GIPR, PGC, ABCB11 | MYC 4193/4885WDR5 3457/4885MAPT 4058/4885 |
| US-10238637-B2 | Modulators of the adenosine A3 receptors | ADORA3, ADORA2A, ADORA1 | MYC 4788/4885WDR5 3585/4885MAPT 3832/4885 |
| US-10913714-B2 | Pyrrole sulfonyl derivative, preparation method and medical use thereof | GIPR, PGC, ABCB11 | MYC 4193/4885WDR5 3457/4885MAPT 4058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.