Sugi Predict

Sugi Predict / Compounds / SCHEMBL19640150

SCHEMBL19640150

SCHEMBL19640150

C#CCOc1cc(O)ccc1C=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 3/20 0.41
▸ TSHR P16473 1/20 0.41
▸ LMNA P02545 1/20 0.38
▸ APP P05067 1/20 0.38
▸ ALDH1A1 P00352 2/20 0.37
▸ HTT P42858 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ TRIM24 O15164 1/20 0.37
▸ TYR P14679 1/20 0.37
▸ TRIM33 Q9UPN9 1/20 0.37
▸ BACE1 P56817 1/20 0.36
▸ MAOB P27338 3/20 0.36
▸ GSTP1 P09211 1/20 0.35
▸ PTGDR2 Q9Y5Y4 1/20 0.35
▸ ERN1 O75460 1/20 0.35
▸ MGAM O43451 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ SI P14410 1/20 0.34
▸ MGAM2 Q2M2H8 1/20 0.34
▸ CGAS Q8N884 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20982802 0.82 FDPS (0.42) HPGDTSHRLMNAALDH1A1HTT
SCHEMBL29470912 0.81 TSHR (0.42) HPGDTSHRLMNAALDH1A1HTT
SCHEMBL26082494 0.81 HPGD (0.41) HPGDTSHRLMNAALDH1A1HTT
SCHEMBL15240136 0.81 HPGD (0.55) HPGDTSHRLMNAALDH1A1HTT
SCHEMBL29955556 0.81 MAOB (0.39) HPGDTSHRLMNAALDH1A1HTT
SCHEMBL295293 0.78 ALDH1A1 (0.51) HPGDLMNAAPPALDH1A1HTT
SCHEMBL9636031 0.77 TYR (0.56) TSHRALDH1A1TRIM24TYRTRIM33
SCHEMBL5308227 0.77 ALDH1A1 (0.47) HPGDAPPALDH1A1HTTSMN1; SMN2
SCHEMBL825342 0.76 ALDH1A1 (0.66) HPGDTSHRLMNAALDH1A1HTT
SCHEMBL29953636 0.76 ALDH1A1 (0.66) HPGDTSHRLMNAALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111344018-B Carfilzomib polyethylene glycol Stable compositions of compounds 美国安进公司 2025-06-10 — — CN disclosed
US-20250177540-A1 STABLE COMPOSITIONS OF PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. 2025-06-05 — — US disclosed
US-20230048560-A1 STABLE COMPOSITIONS OF PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. 2023-02-16 — — US disclosed
US-20230048560-A1 STABLE COMPOSITIONS OF PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. 2023-02-16 — — US disclosed
CN-109415353-B Pegylated carfilzomib compounds 美国安进公司 2023-01-10 — — CN disclosed
EP-3464277-B1 PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC (US) 2022-12-28 — — EP disclosed
EP-3464277-B1 PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC (US) 2022-12-28 — — EP disclosed
US-11241502-B2 Stable compositions of pegylated carfilzomib compounds AMGEN INC. (US) 2022-02-08 — — US disclosed
US-11241502-B2 Stable compositions of pegylated carfilzomib compounds AMGEN INC. (US) 2022-02-08 — — US disclosed
US-11077198-B2 Pegylated carfilzomib compounds AMGEN INC. (US) 2021-08-03 — — US disclosed
US-10675353-B2 Pegylated carfilzomib compounds AMGEN INC. (US) 2020-06-09 — — US disclosed
US-10675353-B2 Pegylated carfilzomib compounds AMGEN INC. (US) 2020-06-09 — — US disclosed
US-20200069808-A1 PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. 2020-03-05 — — US disclosed
US-20200069808-A1 PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. 2020-03-05 — — US disclosed
US-20190142957-A1 STABLE COMPOSITIONS OF PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. 2019-05-16 — — US disclosed
US-20190142957-A1 STABLE COMPOSITIONS OF PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. 2019-05-16 — — US disclosed
WO-2017205392-A1 PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. (US) 2017-11-30 — — WO disclosed
US-20170340746-A1 PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. 2017-11-30 — — US disclosed
US-20170340746-A1 PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. 2017-11-30 — — US disclosed
US-20170340746-A1 PEGYLATED CARFILZOMIB COMPOUNDS AMGEN INC. 2017-11-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170340746-A1 PEGYLATED CARFILZOMIB COMPOUNDS MCL1, FCGRT, MAN2B1 HPGD 3908/4885TSHR 2522/4885LMNA 1639/4885
US-20190142957-A1 STABLE COMPOSITIONS OF PEGYLATED CARFILZOMIB COMPOUNDS MCL1, PHOSPHO1, PSMB5 HPGD 3351/4885TSHR 3971/4885LMNA 582/4885
US-20230048560-A1 STABLE COMPOSITIONS OF PEGYLATED CARFILZOMIB COMPOUNDS MCL1, PHOSPHO1, PSMB5 HPGD 3351/4885TSHR 3971/4885LMNA 582/4885
US-11077198-B2 Pegylated carfilzomib compounds FCGRT, EPOR, MCL1 HPGD 4033/4885TSHR 2276/4885LMNA 1034/4885
US-11241502-B2 Stable compositions of pegylated carfilzomib compounds MCL1, PHOSPHO1, PSMB5 HPGD 3351/4885TSHR 3971/4885LMNA 582/4885
US-20250177540-A1 STABLE COMPOSITIONS OF PEGYLATED CARFILZOMIB COMPOUNDS MCL1, PHOSPHO1, PSMB5 HPGD 3351/4885TSHR 3971/4885LMNA 582/4885
US-10675353-B2 Pegylated carfilzomib compounds FCGRT, EPOR, MCL1 HPGD 4033/4885TSHR 2276/4885LMNA 1034/4885
US-20200069808-A1 PEGYLATED CARFILZOMIB COMPOUNDS FCGRT, EPOR, MCL1 HPGD 4033/4885TSHR 2276/4885LMNA 1034/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.