Isosorbide

Isosorbide

SCHEMBL196416

O[C@@H]1CO[C@H]2[C@H]1OC[C@H]2O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ THRB P10828 1/20 1.00
▸ LMNA P02545 1/20 1.00
▸ MAPT P10636 1/20 0.48
▸ BCHE P06276 1/20 0.33
▸ FUCA1 P04066 1/20 0.30
▸ GBA1 P04062 1/20 0.30
▸ GLA P06280 1/20 0.30
▸ GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isosorbide SCHEMBL822850 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL9915547 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL83297 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL824823 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL12504733 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL5884995 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL24465084 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL9915550 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL2599531 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL15495 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 645 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025104118-A1 FLAME-RETARDANT COMPOSITION BASED ON BIO-BASED POLYCARBONATE COPOLYMER, FOR USE IN 3D PRINTING 4D PIONEERS (FR) 2025-05-22 — — WO claimed
EP-4543851-A1 METHOD AND DEVICE FOR PRODUCING ISOCYANATES Covestro Deutschland AG (DE) 2025-04-30 — — EP claimed
US-12226507-B2 Use of dianhydrohexitol in oral and dental care to reduce the development of bacterial strains ROQUETTE FRERES (FR) 2025-02-18 — — US claimed
US-12180335-B2 Polycarbonate diol derived from ether diol of anhdrohexitol and preparation method thereof, and polyurethane prepared therefrom and adhesive comprising the same SAMYANG CORPORATION (KR) 2024-12-31 — — US claimed
WO-2023247523-A1 METHOD AND DEVICE FOR PRODUCING ISOCYANATES COVESTRO DEUTSCHLAND AG (DE) 2023-12-28 — — WO claimed
EP-4296261-A1 METHOD AND DEVICE FOR PRODUCING ISOCYANATES Covestro Deutschland AG (DE) 2023-12-27 — — EP claimed
CN-116478382-A Aromatic heat-resistant toughened polyester and preparation method thereof 复旦大学 2023-07-25 — — CN claimed
US-20220356619-A1 MOISTURE ABSORBING FABRRIC BLEND GARNER JOHN (US) 2022-11-10 — — US claimed
US-20220227927-A1 ETHER DIOL-DERIVED POLYCARBONATE DIOL OF ANHYDROHEXITOL, METHOD FOR PREPARING SAME, POLYURETHANE PREPARED FROM SAME AND ADHESIVE COMPRISING SAME SAMYANG CORPORATION (KR) 2022-07-21 — — US claimed
EP-3978545-A1 ETHER DIOL-DERIVED POLYCARBONATE DIOL OF ANHYDROHEXITOL, METHOD FOR PREPARING SAME, POLYURETHANE PREPARED FROM SAME AND ADHESIVE COMPRISING SAME Samyang Corporation (KR) 2022-04-06 — — EP claimed
WO-1999054534-A9 POLYESTER FIBER AND METHODS FOR MAKING SAME DU PONT (US) 2000-01-27 — — WO claimed
WO-1999054534-A1 POLYESTER FIBER AND METHODS FOR MAKING SAME E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-10-28 — — WO claimed
WO-1999054378-A1 OPTICAL ARTICLES COMPRISING ISOSORBIDE POLYESTERS AND METHOD FOR MAKING SAME E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-10-28 — — WO claimed
WO-1999054529-A1 POLYESTER FILM AND METHODS FOR MAKING SAME E.I DUPONT DE NEMOURS AND COMPANY (US) 1999-10-28 — — WO claimed
US-5959066-A COMBINING IN A REACTOR A TEREPHTHALOYL MOIETY, AN AROMATIC DIACID, ETHYLENE GLYCOL MOIETY AND AN ISOSORBIDE MOIETY, AND A CONDENSATION CATALYST; HEATING TO YIELD AN ISOTROPIC POLYESTER SUITABLE FOR FILMS, BEVERAGE BOTTLES, MOLDINGS HNA HOLDINGS, INC. (US) 1999-09-28 — — US claimed
US-5958581-A FORM TEREPHTHALIC ACID, ETHYLENE GLYCOL AND ISOSORBIDE MIXTURES HNA HOLDINGS, INC. (US) 1999-09-28 — — US claimed
EP-0323994-B1 PROCESS FOR PREPARING ANHYDRIDES OF HEXITOLS, HEXONOLACTONES, HEXOSES AND HEXOSIDES ERIDANIA BEGHIN-SAY (FR) 1993-03-31 — — EP claimed
EP-0114270-B1 ACYL DERIVATIVES OF 1,4:3,6-DIANHYDRO-HEXITOLES, METHOD FOR THEIR PREPARATION AND THEIR PHARMAZEUTICAL USE Heinrich Mack Nachf. (DE) 1987-04-01 — — EP claimed
US-4564692-A Process for recovering pure crystalline monoanhydrohexitols and dianhydrohexitols CPC INTERNATIONAL INC. (US) 1986-01-14 — — US claimed
US-4559351-A Dihydropyridine derivatives of 1,4:3,6-dianhydrohexitols HEINRICH MACK NACHF. (DE) 1985-12-17 — — US claimed
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