Isosorbide

Isosorbide

SCHEMBL83297

O[C@@H]1COC2C1OC[C@@H]2O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ THRB P10828 1/20 1.00
▸ LMNA P02545 1/20 1.00
▸ MAPT P10636 1/20 0.48
▸ BCHE P06276 1/20 0.33
▸ FUCA1 P04066 1/20 0.30
▸ GBA1 P04062 1/20 0.30
▸ GLA P06280 1/20 0.30
▸ GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isosorbide SCHEMBL822850 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL9915547 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL824823 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL12504733 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL5884995 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL24465084 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL9915550 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL2599531 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL15495 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1
Isosorbide SCHEMBL196416 1.00 THRB (1.00) THRBLMNAMAPTBCHEFUCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240209145-A1 POLYCARBONATE RESIN COMPOSITION HAVING EXCELLENT OPTICAL CHARACTERISTICS AND MOLDED PRODUCT COMPRISING SAME SAMYANG CORPORATION (KR) 2024-06-27 — — US disclosed
US-20240209145-A1 POLYCARBONATE RESIN COMPOSITION HAVING EXCELLENT OPTICAL CHARACTERISTICS AND MOLDED PRODUCT COMPRISING SAME SAMYANG CORPORATION (KR) 2024-06-27 — — US disclosed
WO-2023184852-A1 SHAPE MEMORY POLYURETHANE AND SELF-REINFORCED REGULAR POROUS POLYMER FILM PREPARED FROM SAME 重庆大学 2023-10-05 — — WO disclosed
WO-2023180658-A1 METHOD FOR PREPARING A POLYURETHANE FOAM Universite de Bordeaux (FR) 2023-09-28 — — WO disclosed
US-11753414-B2 Compositions and methods for treating atopic dermatitis SYTHEON LTD (US) 2023-09-12 — — US disclosed
US-11753414-B2 Compositions and methods for treating atopic dermatitis SYTHEON LTD (US) 2023-09-12 — — US disclosed
US-11753415-B2 Compositions and methods for treating atopic dermatitis SYTHEON LTD (US) 2023-09-12 — — US disclosed
US-11753415-B2 Compositions and methods for treating atopic dermatitis SYTHEON LTD (US) 2023-09-12 — — US disclosed
EP-3870626-B1 POLYESTERS, POLYMER COMPOSITIONS, AND METHODS OF USING THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2023-07-12 — — EP disclosed
US-20230167126-A1 Compositions and Methods for Treating Atopic Dermatitis SYTHEON LTD (US) 2023-06-01 — — US disclosed
US-7440160-B2 Electro-optical light modulating element, electro-optical display and modulating medium MERCK PATENT GMBH (DE) 2008-10-21 — — US disclosed
US-7416765-B2 Polymerizable liquid crystalline composition and liquid crystal film made from the composition NIPPON OIL CORPORATION (JP) 2008-08-26 — — US disclosed
US-7416765-B2 Polymerizable liquid crystalline composition and liquid crystal film made from the composition NIPPON OIL CORPORATION (JP) 2008-08-26 — — US disclosed
US-20070267599-A1 Liquid crystal compositions and polymer networks derived therefrom GOLDFINGER MARC B 2007-11-22 — — US disclosed
US-20070267599-A1 Liquid crystal compositions and polymer networks derived therefrom GOLDFINGER MARC B 2007-11-22 — — US disclosed
WO-2007120459-A2 CHIRAL DIOLE COMPOUNDS, LIQUID CRYSTAL COMPOSITIONS AND POLYMER NETWORKS DERIVED THEREFROM E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-10-25 — — WO disclosed
US-7252785-B2 Composition of a radiation-absorbing tert-alkylphenoxy-substituted polycyclic ccmpound and a curable IR-reflecting component of achiral nematic polymerizable monomer, a chiral polymerizable monomer, a cholesteric polymerizable monomer, and a cholesteric polymer in a polymerizable diluent BASF AKTIENGESELLSCHAFT (DE) 2007-08-07 — — US disclosed
US-7252785-B2 Composition of a radiation-absorbing tert-alkylphenoxy-substituted polycyclic ccmpound and a curable IR-reflecting component of achiral nematic polymerizable monomer, a chiral polymerizable monomer, a cholesteric polymerizable monomer, and a cholesteric polymer in a polymerizable diluent BASF AKTIENGESELLSCHAFT (DE) 2007-08-07 — — US disclosed
US-20070164255-A1 POLYMERIZABLE LIQUID CRYSTALLINE COMPOSITION AND LIQUID CRYSTAL FILM MADE FROM THE COMPOSITION NIPPON OIL CORPORATION (JP) 2007-07-19 — — US disclosed
EP-1803773-A1 POLYMERIZABLE LIQUID-CRYSTAL COMPOSITION AND LIQUID-CRYSTAL FILM MADE FROM THE COMPOSITION Nippon Oil Corporation (JP) 2007-07-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070267599-A1 Liquid crystal compositions and polymer networks derived therefrom F2, CCNB1, CYP2F1 THRB 3661/4885LMNA 585/4885MAPT 2560/4885
US-11753415-B2 Compositions and methods for treating atopic dermatitis DHCR7, CYP46A1, NR1H3 THRB 4675/4885LMNA 1287/4885MAPT 197/4885
US-20230167126-A1 Compositions and Methods for Treating Atopic Dermatitis DHCR7, CYP46A1, NR1H3 THRB 4675/4885LMNA 1287/4885MAPT 197/4885
US-11753414-B2 Compositions and methods for treating atopic dermatitis DHCR7, CYP46A1, NR1H3 THRB 4675/4885LMNA 1287/4885MAPT 197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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