Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.52 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL620074 | 0.83 | POLB (0.66) | MMP13SPHK2SPHK1KMT2APOLB | |
| SCHEMBL12414159 | 0.82 | MMP13 (0.61) | MMP13NPC1RAB9ASMN1; SMN2SPHK2 | |
| SCHEMBL19835597 | 0.81 | MMP13 (0.74) | MMP13NPC1RAB9ASMN1; SMN2SPHK2 | |
| SCHEMBL15459742 | 0.81 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL6024439 | 0.81 | NPC1 (0.75) | MMP13NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL23471096 | 0.80 | POLB (0.58) | MMP13SMN1; SMN2SPHK2SPHK1POLB | |
| SCHEMBL1246967 | 0.79 | LMNA (0.61) | NPC1RAB9ASMN1; SMN2SPHK2SPHK1 | |
| SCHEMBL305562 | 0.77 | GAA (0.65) | NPC1RAB9ASMN1; SMN2SPHK2SPHK1 | |
| SCHEMBL19835594 | 0.77 | TRPV1 (0.64) | MMP13 | |
| SCHEMBL7296744 | 0.76 | SPHK2 (0.80) | NPC1RAB9ASMN1; SMN2SPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9827326-B2 | Polymer-sunitinib conjugates | NEKTAR THERAPEUTICS (US) | 2017-11-28 | — | — | US | disclosed |