Sugi Predict

Sugi Predict / Compounds / SCHEMBL305562

SCHEMBL305562

SCHEMBL305562

O=C(NCCO)c1ccccc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 1/20 0.65
▸ SMN1; SMN2 Q16637 4/20 0.63
▸ POLB P06746 3/20 0.63
▸ LMNA P02545 2/20 0.63
▸ NPC1 O15118 4/20 0.61
▸ RAB9A P51151 4/20 0.61
▸ EPHX2 P34913 1/20 0.61
▸ PRSS1 P07477 1/20 0.61
▸ CTSG P08311 1/20 0.61
▸ CTRB1 P17538 1/20 0.61
▸ CMA1 P23946 1/20 0.61
▸ KMT2A Q03164 1/20 0.61
▸ HPGD P15428 3/20 0.59
▸ RECQL P46063 1/20 0.59
▸ NAAA Q02083 1/20 0.59
▸ HDAC3 O15379 1/20 0.59
▸ HDAC4 P56524 1/20 0.59
▸ HDAC1 Q13547 1/20 0.59
▸ HDAC7 Q8WUI4 1/20 0.59
▸ HDAC2 Q92769 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6421806 0.98 GAA (0.63) GAASMN1; SMN2POLBLMNANPC1
Benzoic Acid SCHEMBL3096844 0.94 GAA (0.59) GAASMN1; SMN2POLBLMNANPC1
SCHEMBL1246967 0.92 LMNA (0.61) GAASMN1; SMN2POLBLMNANPC1
Thiosulfuric Acid SCHEMBL11092443 0.89 HDAC3 (0.58) GAASMN1; SMN2POLBLMNANPC1
Thiosulfuric Acid SCHEMBL11092446 0.89 HDAC3 (0.54) GAASMN1; SMN2POLBLMNANPC1
SCHEMBL620074 0.89 POLB (0.66) POLBLMNAKMT2AHPGDHDAC4
SCHEMBL3192014 0.89 LMNA (0.77) GAASMN1; SMN2POLBLMNANPC1
SCHEMBL11251484 0.88 LMNA (0.61) GAASMN1; SMN2POLBLMNANPC1
SCHEMBL6716169 0.88 NPC1 (0.66) SMN1; SMN2POLBLMNANPC1RAB9A
SCHEMBL2021484 0.88 NPC1 (0.68) GAASMN1; SMN2POLBLMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 491 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12208088-B2 Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof GENENTECH, INC. (US) 2025-01-28 — — US claimed
US-20240374582-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF Genosco Inc. 2024-11-14 — — US claimed
US-12064426-B2 Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof Genosco Inc. (US) 2024-08-20 — — US claimed
CN-118240193-A Preparation method of recyclable N-acylated polyaminoester 苏州大学 2024-06-25 — — CN claimed
CN-117136186-A Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof 盖诺斯克公司 2023-11-28 — — CN claimed
US-20230082993-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. 2023-03-16 — — US claimed
EP-3275440-B1 NOVEL OXADIAZOLE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME NAT CT GERIATRICS & GERONTOLOGY (JP) 2022-05-04 — — EP claimed
CN-110903210-A Preparation method of organic intermediate N, N-bis (β -hydroxyethyl) benzamide 江苏鑫露化工新材料有限公司 2020-03-24 — — CN claimed
EP-3303291-A1 ROR GAMMA (ROR ) MODULATORS Lead Pharma Holding B.V. (NL) 2018-04-11 — — EP claimed
WO-2016193452-A1 ROR GAMMA (RORγ) MODULATORS LEAD PHARMA CEL MODELS IP B.V. (NL) 2016-12-08 — — WO claimed
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents JAPAN TOBACCO INC. (JP) 2007-02-08 — — US claimed
JP-2006519232-A — — 2006-08-24 — — JP claimed
EP-1603570-A2 AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS Sugen, Inc. (US) 2005-12-14 — — EP claimed
US-20050043396-A1 5-Benzoylamino-1,3-dioxacyclanes, the method for preparing the same and their use as PKC inhibitor ZEN HAYLEY (CN) 2005-02-24 — — US claimed
EP-1490064-A1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE Pharmacia Corporation (US) 2004-12-29 — — EP claimed
WO-2004076412-A2 AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS SUGEN, INC. (US) 2004-09-10 — — WO claimed
WO-2003068230-A1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE PHARMACIA CORPORATION (US) 2003-08-21 — — WO claimed
US-6458865-B2 FOR DENTAL RESTORATION MATERIAL CURATORS OF THE UNIVERSITY OF MISSOURI 2002-10-01 — — US claimed
EP-0339976-B1 Anti-tumour agents ICI PLC (GB) 1994-02-02 — — EP claimed
EP-0339976-A1 Anti-tumour agents IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1989-11-02 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12064426-B2 Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof ROCK2, ROCK1, MYLK3 GAA 3553/4885SMN1; SMN2 2583/4885POLB 3264/4885
US-12208088-B2 Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof HIPK1, NEK1, HIPK2 GAA 2833/4885SMN1; SMN2 3280/4885POLB 3416/4885
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents PYGL, GYS2, AGL GAA 53/4885SMN1; SMN2 4705/4885POLB 3038/4885
US-20230082993-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF ROCK2, ROCK1, MYLK3 GAA 3553/4885SMN1; SMN2 2583/4885POLB 3264/4885
US-20240374582-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF ROCK2, ROCK1, MYLK3 GAA 3360/4885SMN1; SMN2 2301/4885POLB 3092/4885
US-20050043396-A1 5-Benzoylamino-1,3-dioxacyclanes, the method for preparing the same and their use as PKC inhibitor PRKCA, PRKCD, PRKCB GAA 781/4885SMN1; SMN2 4752/4885POLB 2845/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.