Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28890228 | 0.92 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL11674046 | 0.91 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| Triethylene Glycol SCHEMBL11674048 | 0.88 | ALDH1A1 (0.44) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| Propane SCHEMBL28408609 | 0.87 | GAA (0.54) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| Propane SCHEMBL3563886 | 0.87 | GAA (0.54) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL921765 | 0.86 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| Alcohol SCHEMBL282126 | 0.85 | GAA (0.52) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL2952900 | 0.85 | GAA (0.52) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| Butane SCHEMBL27630383 | 0.85 | GAA (0.52) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL11432043 | 0.85 | GAA (0.62) | ALDH1A1LMNASMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110140187-A | Electrolyte comprising 3, 4-ethylenedioxythiophene, electrolytic capacitor comprising the same, and raw material for electronic material | 株式会社东进世美肯 | 2019-08-16 | — | — | CN | disclosed |
| US-9745273-B2 | Phenazine derivatives as anti-neoplastic agents and anti-infective agents | UNIVERSITETET I OSLO (NO) | 2017-08-29 | — | — | US | disclosed |
| CN-106715529-A | Process for preparing polymers | 帝国创新有限公司 | 2017-05-24 | — | — | CN | disclosed |
| EP-3063136-A2 | PHENAZINE DERIVATIVES AS ANTI-CANCER AND ANTI-INFECTIVE AGENTS | Universitetet I Oslo (NO) | 2016-09-07 | — | — | EP | disclosed |
| US-20160251320-A1 | Compounds | UNIVERSITÉ CLAUDE BERNARD LYON 1 (FR) | 2016-09-01 | — | — | US | disclosed |
| WO-2015063516-A2 | COMPOUNDS | UNIVERSITETET I OSLO (NO) | 2015-05-07 | — | — | WO | disclosed |
| CN-101998956-B | Fluorinated dihydrotetrabenazine ether imaging agents and probes | GENERAL ELECTRIC CO. (US) | 2014-10-22 | — | — | CN | disclosed |
| US-20110144373-A1 | WATER-SOLUBLE DEGRADABLE PHOTO-CROSSLINKER | SURMODICS, INC. (US) | 2011-06-16 | — | — | US | disclosed |
| WO-2011072199-A2 | WATER-SOLUBLE DEGRADABLE PHOTO-CROSSLINKER | SURMODICS, INC. (US) | 2011-06-16 | — | — | WO | disclosed |
| CN-101998956-A | Fluorinated dihydrotetrabenazine ether imaging agents and probes | GEN ELECTRIC | 2011-03-30 | — | — | CN | disclosed |
| US-4857599-A | Modified dense star polymers | THE DOW CHEMICAL COMPANY (US) | 1989-08-15 | — | — | US | disclosed |
| US-4694064-A | Rod-shaped dendrimer | THE DOW CHEMICAL COMPANY (US) | 1987-09-15 | — | — | US | disclosed |
| EP-0234408-A2 | Rod-shaped dendrimers | THE DOW CHEMICAL COMPANY (US) | 1987-09-02 | — | — | EP | disclosed |
| US-4686237-A | LOWERING BLOOD CHOLESTEROL LEVEL | SANDOZ PHARMACEUTICALS CORP. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4587329-A | Dense star polymers having two dimensional molecular diameter | THE DOW CHEMICAL COMPANY (US) | 1986-05-06 | — | — | US | disclosed |
| US-4568737-A | Dense star polymers and dendrimers | THE DOW CHEMICAL COMPANY (US) | 1986-02-04 | — | — | US | disclosed |
| US-4558120-A | Dense star polymer | THE DOW CHEMICAL COMPANY (US) | 1985-12-10 | — | — | US | disclosed |
| EP-0115771-A2 | Dense star polymers and a process for producing dense star polymers | THE DOW CHEMICAL COMPANY (US) | 1984-08-15 | — | — | EP | disclosed |
| WO-1984002705-A1 | DENSE STAR POLYMERS AND A PROCESS FOR PRODUCING DENSE STAR POLYMERS | DOW CHEMICAL CO (US) | 1984-07-19 | — | — | WO | disclosed |
| US-4409141-A | Peptides for assaying human parathyroid hormone | TOYO JOZO KABUSHIKI KAISHA (JP) | 1983-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144373-A1 | WATER-SOLUBLE DEGRADABLE PHOTO-CROSSLINKER | PLG, USP28, DCLRE1A | ALDH1A1 1181/4885LMNA 2297/4885SMN1; SMN2 4105/4885 |
| US-20160251320-A1 | Compounds | NISCH, MDN1, PIR | ALDH1A1 4618/4885LMNA 593/4885SMN1; SMN2 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.