Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.62 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.62 |
| ▸ | BAX | Q07812 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.52 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.52 |
| ▸ | FEN1 | P39748 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL360280 | 1.00 | LTA4H (0.75) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL5606885 | 1.00 | LTA4H (0.75) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL7033901 | 0.89 | LTA4H (0.60) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL9846088 | 0.89 | LTA4H (0.60) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL10618785 | 0.88 | PARP10 (0.71) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL29175285 | 0.88 | LTA4H (0.67) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL1830446 | 0.88 | LTA4H (0.67) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL7637273 | 0.88 | LTA4H (0.67) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL28412058 | 0.88 | LTA4H (0.67) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL8165466 | 0.88 | PARP10 (0.71) | LTA4HTSHRPARP10NR1H2BAX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687370-B1 | POLYESTER-BASED DEPOSITION FILM | KOLON INC (KR) | 2020-04-29 | — | — | EP | claimed |
| EP-2687369-B1 | POLYESTER-BASED DEPOSITED FILM | KOLON INC (KR) | 2018-03-07 | — | — | EP | claimed |
| EP-2555053-B1 | POSITIVE-TYPE PHOTOSENSITIVE RESIN COMPOSITION | TORAY INDUSTRIES (JP) | 2017-10-18 | — | — | EP | claimed |
| EP-2510401-B1 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS | CANON KK (JP) | 2015-02-25 | — | — | EP | disclosed |
| US-8785089-B2 | Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus | CANON KABUSHIKI KAISHA (JP) | 2014-07-22 | — | — | US | disclosed |
| EP-2510401-A1 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS | Canon Kabushiki Kaisha (JP) | 2012-10-17 | — | — | EP | disclosed |
| US-20120243904-A1 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS | CANON KABUSHIKI KAISHA (JP) | 2012-09-27 | — | — | US | disclosed |
| US-8017722-B2 | Polycarbonate containing plant-derived component and process for the preparation thereof | TEIJIN LIMITED (JP) | 2011-09-13 | — | — | US | disclosed |
| WO-2011071093-A1 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS | CANON KABUSHIKI KAISHA (JP) | 2011-06-16 | — | — | WO | disclosed |
| US-20100160601-A1 | POLYCARBONATE CONTAINING PLANT-DERIVED COMPONENT AND PROCESS FOR THE PREPARATION THEREOF | TEIJIN LIMITED (JP) | 2010-06-24 | — | — | US | disclosed |
| EP-2147945-A1 | METHOD FOR PRODUCTION OF POLYCARBONATE CONTAINING PLANT-DERIVED COMPONENT | Teijin Limited (JP) | 2010-01-27 | — | — | EP | disclosed |