Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | BAX | Q07812 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL296590 | 0.89 | LTA4H (0.75) | LTA4HTSHRHPGDNPC1CRHBP | |
| Diphenylether SCHEMBL1965337 | 0.89 | LTA4H (0.75) | LTA4HTSHRHPGDPARP10FFAR1 | |
| Diphenylether SCHEMBL5606885 | 0.89 | LTA4H (0.75) | LTA4HTSHRHPGDPARP10FFAR1 | |
| Diphenylether SCHEMBL360280 | 0.89 | LTA4H (0.75) | LTA4HTSHRHPGDPARP10FFAR1 | |
| Diphenylether SCHEMBL8533552 | 0.88 | LTA4H (0.57) | LTA4HTSHRHPGDNPC1CRHBP | |
| Diphenylether SCHEMBL27521612 | 0.86 | LTA4H (0.55) | LTA4HTSHRHPGDNPC1CRHBP | |
| Diphenylether SCHEMBL7544612 | 0.85 | TGM2 (0.54) | LTA4HTSHRHPGDNPC1CRHBP | |
| Diphenylether SCHEMBL1830446 | 0.84 | LTA4H (0.67) | LTA4HTSHRHPGDRAB9APARP10 | |
| Diphenylether SCHEMBL8691831 | 0.84 | LTA4H (0.67) | LTA4HTSHRHPGDNPC1CRHBP | |
| Diphenylether SCHEMBL29175285 | 0.84 | LTA4H (0.67) | LTA4HTSHRHPGDRAB9APARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278603-A2 | A SPRAYING DEVICE FOR DISPENSING HOME CARE FORMULATIONS WITH ELECTROSTATIC LIQUID DROPLETS | Sarnoff Corporation (US) | 2003-01-29 | — | — | EP | disclosed |
| US-6474563-B2 | Spraying device for dispensing home care formulations with electrostatic liquid droplets | SARNOFF CORPORATION | 2002-11-05 | — | — | US | disclosed |
| WO-2001083116-A2 | A SPRAYING DEVICE FOR DISPENSING HOME CARE FORMULATIONS WITH ELECTROSTATIC LIQUID DROPLETS | SARNOFF CORPORATION (US) | 2001-11-08 | — | — | WO | disclosed |