Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.62 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.62 |
| ▸ | BAX | Q07812 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.52 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.52 |
| ▸ | FEN1 | P39748 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL1965337 | 1.00 | LTA4H (0.75) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL360280 | 1.00 | LTA4H (0.75) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL7033901 | 0.89 | LTA4H (0.60) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL9846088 | 0.89 | LTA4H (0.60) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL10618785 | 0.88 | PARP10 (0.71) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL29175285 | 0.88 | LTA4H (0.67) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL1830446 | 0.88 | LTA4H (0.67) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL7637273 | 0.88 | LTA4H (0.67) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL28412058 | 0.88 | LTA4H (0.67) | LTA4HTSHRPARP10NR1H2BAX | |
| Diphenylether SCHEMBL8165466 | 0.88 | PARP10 (0.71) | LTA4HTSHRPARP10NR1H2BAX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2832768-B1 | PREPARATION METHOD OF POLYIMIDE | CHANGCHUN HIPOLYKING CO LTD (CN) | 2017-07-05 | — | — | EP | claimed |
| EP-1123348-B1 | IMPACT-RESISTANT EPOXIDE RESIN COMPOSITIONS | HENKEL TEROSON GMBH (DE) | 2005-12-28 | — | — | EP | claimed |
| EP-1272587-B1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | HENKEL KGAA (DE) | 2004-05-19 | — | — | EP | claimed |
| EP-0962459-B1 | DIACETAL COMPOSITION, PROCESS FOR THE PREPARATION OF THE SAME, NUCLEATING AGENT FOR POLYOLEFINS CONTAINING THE SAME, POLYOLEFIN RESIN COMPOSITIONS, AND MOLDINGS | NEW JAPAN CHEM CO LTD (JP) | 2003-10-01 | — | — | EP | claimed |
| EP-1272587-A1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-01-08 | — | — | EP | claimed |
| WO-2001094492-A1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2001-12-13 | — | — | WO | claimed |
| EP-1123348-A2 | IMPACT-RESISTANT EPOXIDE RESIN COMPOSITIONS | Henkel Teroson GmbH (DE) | 2001-08-16 | — | — | EP | claimed |
| WO-2000020483-A2 | IMPACT-RESISTANT EPOXIDE RESIN COMPOSITIONS | HENKEL TEROSON GMBH (DE) | 2000-04-13 | — | — | WO | claimed |
| EP-0701996-A1 | Process for the separation of aminodiphenyl from diphenylamine | BAYER AG (DE) | 1996-03-20 | — | — | EP | claimed |
| EP-2231327-B1 | CATALYST COMPOSITION INCLUDING ZIRCONIUM COMPOUNDS FOR ESTERFICATION REACTION AND METHOD FOR PREPARING ESTER COMPOUNDS | LG CHEMICAL LTD (KR) | 2013-10-16 | — | — | EP | disclosed |
| CN-1834048-B | Synthetic silicates and use thereof in glass production | MINERALS TECH INC | 2010-10-20 | — | — | CN | disclosed |
| EP-1456321-B1 | MULTI-PHASE STRUCTURAL ADHESIVES | HENKEL KGAA (DE) | 2007-04-18 | — | — | EP | disclosed |
| CN-1281545-C | Synthetic silicates and their use in glass production | MINERALS TECH INC (US) | 2006-10-25 | — | — | CN | disclosed |
| CN-1834048-A | Method of producing synthetic silicates and use thereof in glass production | MINERALS TECH INC (US) | 2006-09-20 | — | — | CN | disclosed |
| EP-1272587-A1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001094492-A1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2001-12-13 | — | — | WO | disclosed |
| EP-1123348-A2 | IMPACT-RESISTANT EPOXIDE RESIN COMPOSITIONS | Henkel Teroson GmbH (DE) | 2001-08-16 | — | — | EP | disclosed |
| CN-1283170-A | Synthetic silicates and their use in glass production | MINERALS TECH INC (US) | 2001-02-07 | — | — | CN | disclosed |
| WO-2000020483-A2 | IMPACT-RESISTANT EPOXIDE RESIN COMPOSITIONS | HENKEL TEROSON GMBH (DE) | 2000-04-13 | — | — | WO | disclosed |
| EP-0701996-A1 | Process for the separation of aminodiphenyl from diphenylamine | BAYER AG (DE) | 1996-03-20 | — | — | EP | disclosed |