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SCHEMBL1965537

SCHEMBL1965537

COC(C(=O)Nc1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccccc2)c1)C(C(=O)Nc1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccccc2)c1)c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 12/20 0.49
▸ LMNA P02545 7/20 0.49
▸ CACNA1H O95180 1/20 0.49
▸ HTT P42858 3/20 0.49
▸ GAA P10253 1/20 0.49
▸ ALDH1A1 P00352 1/20 0.46
▸ TP53 P04637 1/20 0.46
▸ THRB P10828 1/20 0.46
▸ NR3C1 P04150 2/20 0.46
▸ MEN1 O00255 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ PKM P14618 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL301695 0.79 GAA (0.76) MAPTLMNACACNA1HHTTGAA
SCHEMBL3279971 0.79 MAPT (0.61) MAPTLMNACACNA1HHTTGAA
SCHEMBL3278531 0.76 HTT (0.57) MAPTLMNACACNA1HHTTGAA
SCHEMBL1964073 0.76 GAA (0.55) MAPTLMNACACNA1HHTTGAA
SCHEMBL1965535 0.76 MAPT (0.57) MAPTLMNACACNA1HHTTGAA
SCHEMBL3377228 0.72 MAPT (0.74) MAPTLMNAHTTGAAALDH1A1
SCHEMBL302171 0.72 MAPT (0.52) MAPTLMNACACNA1HHTTGAA
SCHEMBL302890 0.71 HTT (0.51) MAPTLMNACACNA1HHTTGAA
SCHEMBL302225 0.70 LMNA (0.60) MAPTLMNAHTTGAAALDH1A1
SCHEMBL302889 0.70 LMNA (0.54) MAPTLMNACACNA1HHTTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2334637-A1 NOVEL POTASSIUM CHANNEL BLOCKERS Xention Limited (GB) 2011-06-22 — — EP disclosed