Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.51 |
| ▸ | PDE7A | Q13946 | 9/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657320 | 0.87 | CREBBP (0.52) | CREBBPPDE7ASPRKDM4C | |
| SCHEMBL22822410 | 0.84 | CREBBP (0.50) | CREBBPPDE7ASPRKDM4CSSTR4 | |
| SCHEMBL20594787 | 0.77 | ALDH1A1 (0.43) | TEAD1TEAD4TEAD2 | |
| SCHEMBL15792505 | 0.75 | KDM4C (0.50) | KDM4CPDE1APDE1BPDE1C | |
| SCHEMBL19644534 | 0.73 | CNR2 (0.46) | CREBBPPDE7ASPRKDM4CSSTR4 | |
| SCHEMBL29704358 | 0.73 | CNR2 (0.46) | CREBBPPDE7ASPRKDM4CSSTR4 | |
| SCHEMBL19657665 | 0.69 | CREBBP (0.48) | CREBBPPDE7ASPR | |
| SCHEMBL30159627 | 0.69 | ALDH1A1 (0.41) | — | |
| SCHEMBL9904651 | 0.69 | ALDH1A1 (0.41) | — | |
| SCHEMBL34471842 | 0.69 | GSK3B (0.44) | CREBBPKDM4CPDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |