Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14100439 | 0.89 | KCNH2 (0.53) | KCNH2GPR119DRD2HTR2AHTR2C | |
| SCHEMBL4592218 | 0.87 | CHRM2 (0.64) | KCNH2GPR119DRD2HTR2AHTR2C | |
| SCHEMBL9030647 | 0.87 | SIGMAR1 (0.67) | KCNH2DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL19658765 | 0.86 | OPRM1 (0.56) | KCNH2GPR119L3MBTL1DRD2HTR2A | |
| SCHEMBL19652131 | 0.85 | KCNH2 (0.52) | KCNH2GPR119L3MBTL1DRD2HTR2A | |
| SCHEMBL19658476 | 0.85 | CHRM2 (0.57) | KCNH2GPR119SIGMAR1CHRM2CHRM3 | |
| SCHEMBL19658764 | 0.84 | MEN1 (0.54) | KCNH2GPR119DRD2HTR2AHTR2C | |
| SCHEMBL19658974 | 0.84 | DRD2 (0.54) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL17753009 | 0.83 | ACHE (0.60) | KCNH2L3MBTL1ACHE | |
| SCHEMBL12074554 | 0.82 | ALDH1A1 (0.56) | KCNH2L3MBTL1ACHEALDH1A1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | KCNH2 3447/4885GPR119 988/4885L3MBTL1 3326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.