Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tosufloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | EDNRA | P25101 | 1/20 | 0.58 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | TOP2A | P11388 | 1/20 | 0.55 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ciprofloxacin SCHEMBL5029227 | 0.88 | LMNA (0.75) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| Enrofloxacin SCHEMBL21776638 | 0.85 | KDM4E (0.71) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| Trovafloxacin SCHEMBL7034983 | 0.84 | KDM4E (0.75) | KMT2ALMNACYP2C9KDM4EALDH1A1 | |
| Temafloxacin SCHEMBL28142854 | 0.83 | LMNA (0.65) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| Temafloxacin SCHEMBL21776489 | 0.81 | KMT2A (0.76) | KMT2ALMNACYP2C9ATP6V1B2TBXA2R | |
| Tosufloxacin SCHEMBL34355 | 0.81 | KMT2A (1.00) | KMT2ALMNAKDM4EALDH1A1HPGD | |
| Tosufloxacin SCHEMBL29383684 | 0.81 | KMT2A (1.00) | KMT2ALMNAKDM4EALDH1A1HPGD | |
| Tosufloxacin SCHEMBL9323984 | 0.81 | KMT2A (1.00) | KMT2ALMNAKDM4EALDH1A1HPGD | |
| Tosufloxacin SCHEMBL34354 | 0.81 | KMT2A (1.00) | KMT2ALMNAKDM4EALDH1A1HPGD | |
| Tosufloxacin SCHEMBL19149806 | 0.81 | KMT2A (0.98) | KMT2ALMNAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011069197-A1 | INHALABLE FORMULATIONS | THE UNIVERSITY OF SYDNEY (AU) | 2011-06-16 | — | — | WO | disclosed |