Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Enrofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | HPGD | P15428 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.70 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.70 |
| ▸ | EDNRA | P25101 | 1/20 | 0.70 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.70 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | TOP2A | P11388 | 1/20 | 0.67 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ciprofloxacin SCHEMBL5029227 | 0.96 | LMNA (0.75) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| Enrofloxacin SCHEMBL6044970 | 0.89 | KDM4E (0.89) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| Norfloxacin SCHEMBL8387763 | 0.88 | LMNA (0.84) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| SCHEMBL24321007 | 0.87 | LMNA (0.60) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| Ciprofloxacin SCHEMBL5661134 | 0.86 | ALDH1A1 (0.84) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| Pefloxacin SCHEMBL13725108 | 0.86 | LMNA (0.77) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| Tosufloxacin SCHEMBL1965994 | 0.85 | KMT2A (0.66) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| Ciprofloxacin SCHEMBL1701652 | 0.84 | ALDH1A1 (0.81) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| Enrofloxacin SCHEMBL17554684 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1LMNAHSD17B10HPGD | |
| Enrofloxacin SCHEMBL149150 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1LMNAHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820565-A1 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | Biovinc, LLC. (US) | 2021-05-19 | — | — | EP | disclosed |
| WO-2020014269-A9 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | BIOVINC, LLC. (US) | 2020-03-05 | — | — | WO | disclosed |