Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ciprofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.75 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.75 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.75 |
| ▸ | EDNRA | P25101 | 1/20 | 0.75 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.72 |
| ▸ | HPGD | P15428 | 4/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | TOP2A | P11388 | 1/20 | 0.72 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.72 |
| ▸ | BRD4 | O60885 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enrofloxacin SCHEMBL21776638 | 0.96 | KDM4E (0.71) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Norfloxacin SCHEMBL8387763 | 0.91 | LMNA (0.84) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Ciprofloxacin SCHEMBL5661134 | 0.89 | ALDH1A1 (0.84) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Tosufloxacin SCHEMBL1965994 | 0.88 | KMT2A (0.66) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Ciprofloxacin SCHEMBL1701652 | 0.88 | ALDH1A1 (0.81) | LMNACYP2C9KDM4EALDH1A1HSD17B10 | |
| Pefloxacin SCHEMBL13725108 | 0.87 | LMNA (0.77) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Enoxacin SCHEMBL29384458 | 0.87 | LMNA (1.00) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Enoxacin SCHEMBL2635855 | 0.87 | LMNA (1.00) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Enoxacin SCHEMBL33963 | 0.87 | LMNA (1.00) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Enoxacin SCHEMBL29896709 | 0.86 | LMNA (0.98) | LMNACYP2C9ATP6V1B2TBXA2REDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981921-A2 | SUPER SOFT FOAMS | Tyco Healthcare Group LP (US) | 2008-10-22 | — | — | EP | claimed |
| WO-2007089763-A2 | SUPER SOFT FOAMS | TYCO HEALTHCARE GROUP LP (US) | 2007-08-09 | — | — | WO | claimed |
| US-20070179210-A1 | Super soft foams | TYCO HEALTHCARE GROUP LP (US) | 2007-08-02 | — | — | US | claimed |
| US-20040038936-A1 | Pharmaceutical composition containing viscoelastic substance and medication | TANAKA KOICHIRO (JP) | 2004-02-26 | — | — | US | disclosed |
| US-20020183279-A1 | Pharmaceutical composition containing viscoelastic substance and medication | KOICHIRO TANAKA (JP) | 2002-12-05 | — | — | US | disclosed |