Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MARS1 | P56192 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966964 | 0.76 | KDM4E (0.47) | SRCADRA1DGABRA5GABRA1GRIN1 | |
| SCHEMBL1969356 | 0.74 | EGLN1 (0.49) | KMT2AMEN1ALDH1A1LMNAHTT | |
| SCHEMBL1967481 | 0.71 | GPR132 (0.43) | ADRA1DGABRA5GABRA1KMT2AMEN1 | |
| SCHEMBL1967484 | 0.71 | GPR132 (0.43) | ADRA1DGABRA5GABRA1KMT2AMEN1 | |
| SCHEMBL15225647 | 0.66 | ADRA1D (0.64) | ADRA1DGABRA5GABRA1KMT2APKM | |
| SCHEMBL7984544 | 0.66 | SRC (1.00) | SRCGABRA5GABRA1GRIN1GRIN2B | |
| SCHEMBL4384391 | 0.64 | SRC (0.51) | SRCGABRA5GABRA1GRIN1GRIN2B | |
| SCHEMBL11157121 | 0.64 | ADRA1D (0.52) | ADRA1DGABRA5GABRA1GRIN1GRIN2B | |
| SCHEMBL25827237 | 0.64 | GABRA5 (0.48) | SRCGABRA5GABRA1GRIN1GRIN2B | |
| SCHEMBL3348293 | 0.63 | KDM4E (0.67) | ADRA1DGABRA1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |