Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 3/20 | 0.34 |
| ▸ | CDK13 | Q14004 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | USP5 | P45974 | 1/20 | 0.31 |
| ▸ | GNRHR | P30968 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19669736 | 0.87 | MEN1 (0.45) | KDM4EALDH1A1MEN1KMT2ACDK7 | |
| SCHEMBL19669737 | 0.86 | EGFR (0.32) | EGFRERBB2 | |
| SCHEMBL15600964 | 0.85 | KDM4E (0.41) | KDM4EALDH1A1CDK7CDK13L3MBTL3 | |
| SCHEMBL19669759 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2ASMN1; SMN2BTK | |
| SCHEMBL15600841 | 0.76 | SMN1; SMN2 (0.53) | KDM4EALDH1A1MEN1KMT2ACDK7 | |
| SCHEMBL24637164 | 0.76 | SIGMAR1 (0.36) | EGFRERBB2 | |
| SCHEMBL18030989 | 0.76 | EGFR (0.33) | EGFRERBB2 | |
| SCHEMBL20235763 | 0.72 | ACKR3 (0.35) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL19442310 | 0.72 | MEN1 (0.43) | KDM4EALDH1A1MEN1KMT2ACDK7 | |
| SCHEMBL19669934 | 0.72 | SIGMAR1 (0.39) | KDM4EEGFRHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834571-B2 | Compounds for inhibiting cell proliferation in EGFR-driven cancers | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |