Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18030989 | 0.90 | EGFR (0.33) | EGFRERBB2SIGMAR1 | |
| SCHEMBL19669735 | 0.86 | KDM4E (0.37) | EGFRERBB2 | |
| SCHEMBL15600978 | 0.85 | EGFR (0.34) | EGFRERBB2SIGMAR1 | |
| SCHEMBL19669759 | 0.76 | ALDH1A1 (0.39) | EGFRERBB2 | |
| SCHEMBL24637164 | 0.76 | SIGMAR1 (0.36) | EGFRERBB2SIGMAR1 | |
| SCHEMBL19669736 | 0.74 | MEN1 (0.45) | EGFRERBB2 | |
| SCHEMBL19669934 | 0.72 | SIGMAR1 (0.39) | EGFRSIGMAR1 | |
| SCHEMBL20235763 | 0.70 | ACKR3 (0.35) | EGFRERBB2 | |
| SCHEMBL15600964 | 0.69 | KDM4E (0.41) | EGFRERBB2 | |
| SCHEMBL16665113 | 0.69 | SIGMAR1 (0.38) | EGFRERBB2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834571-B2 | Compounds for inhibiting cell proliferation in EGFR-driven cancers | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |