Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | GPR4 | P46093 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15600836 | 0.89 | SIGMAR1 (0.41) | SIGMAR1EGFRGPR4GAACYP2D6 | |
| SCHEMBL19669759 | 0.82 | ALDH1A1 (0.39) | EGFRKCNH2 | |
| SCHEMBL15600977 | 0.82 | CHRNB2 (0.44) | SIGMAR1EGFRGPR4GAACYP2D6 | |
| SCHEMBL19669736 | 0.80 | MEN1 (0.45) | EGFRKDM4E | |
| SCHEMBL19669735 | 0.72 | KDM4E (0.37) | EGFRHRH3KDM4E | |
| SCHEMBL19669737 | 0.72 | EGFR (0.32) | SIGMAR1EGFR | |
| SCHEMBL19912771 | 0.72 | PKM (0.36) | EGFRJAK2FLT3KDM4EPKM | |
| SCHEMBL19669740 | 0.72 | LMNA (0.38) | EGFRJAK2FLT3KDM4E | |
| SCHEMBL19912779 | 0.71 | SMN1; SMN2 (0.45) | EGFRJAK2FLT3 | |
| SCHEMBL24637162 | 0.71 | EGFR (0.34) | EGFRJAK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834571-B2 | Compounds for inhibiting cell proliferation in EGFR-driven cancers | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |