Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 5/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.34 |
| ▸ | ITGAL | P20701 | 5/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670623 | 0.91 | KARS1 (0.38) | MAP3K12ITGB2ICAM1ITGALCLK2 | |
| SCHEMBL19365294 | 0.89 | VCP (0.35) | SLC34A1MAP3K12CLK2LRRK2KCNH2 | |
| SCHEMBL19670010 | 0.88 | CLK2 (0.34) | SLC34A1MAP3K12ITGB2ICAM1ITGAL | |
| SCHEMBL19670311 | 0.88 | FGFR4 (0.37) | SLC34A1MAP3K12ITGB2ICAM1ITGAL | |
| SCHEMBL16238200 | 0.87 | SCD (0.37) | SLC34A1MAP3K12ITGB2ICAM1ITGAL | |
| SCHEMBL19670356 | 0.86 | MAP3K12 (0.34) | MAP3K12SCDWNT1GSK3BDYRK1A | |
| SCHEMBL19670444 | 0.86 | ITGB2 (0.36) | SLC34A1MAP3K12ITGB2ICAM1ITGAL | |
| SCHEMBL19365654 | 0.84 | HCRTR1 (0.44) | CSF1RMETKDRMAPK1HCRTR1 | |
| SCHEMBL19670498 | 0.84 | KARS1 (0.41) | ITGB2ICAM1ITGALLRRK2KARS1 | |
| SCHEMBL19669954 | 0.84 | KARS1 (0.34) | ITGB2ICAM1ITGALCLK2KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |