Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 5/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 3/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | NPR1 | P16066 | 1/20 | 0.30 |
| ▸ | VCP | P55072 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670397 | 0.92 | RAF1 (0.36) | ALDH1A1TSHRMEN1KMT2ARAF1 | |
| SCHEMBL17618395 | 0.85 | TSHR (0.36) | ALDH1A1HPGDTSHRNPSR1HSD17B10 | |
| SCHEMBL19670575 | 0.85 | EGFR (0.32) | ALDH1A1KDM4EHTTHPGDSWNT3A | |
| SCHEMBL19365256 | 0.83 | RAF1 (0.37) | ALDH1A1TSHRMEN1KMT2ARAF1 | |
| SCHEMBL19670181 | 0.79 | RAF1 (0.35) | RAF1TRPV3 | |
| SCHEMBL19670122 | 0.79 | GRM5 (0.34) | KMT2ARAF1TRPV3EGFR | |
| SCHEMBL16775861 | 0.78 | VCP (0.36) | RAF1EGFRVCP | |
| SCHEMBL19365513 | 0.78 | PRMT5 (0.41) | ALDH1A1TSHR | |
| SCHEMBL17618387 | 0.77 | RAF1 (0.36) | ALDH1A1TSHRRAF1EGFRVCP | |
| SCHEMBL17624556 | 0.77 | RAF1 (0.37) | ALDH1A1TSHRHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |