Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 4/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | NPR1 | P16066 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670137 | 0.85 | ALDH1A1 (0.34) | EGFRKDM4EALDH1A1HTTHPGDS | |
| SCHEMBL17618397 | 0.84 | HPGDS (0.34) | EGFRALDH1A1HPGDSWNT3AADORA3 | |
| SCHEMBL19365513 | 0.83 | PRMT5 (0.41) | ALDH1A1ADORA2A | |
| SCHEMBL19670122 | 0.81 | GRM5 (0.34) | EGFRTRPV3 | |
| SCHEMBL19670181 | 0.80 | RAF1 (0.35) | TRPV3 | |
| SCHEMBL19670257 | 0.80 | HPGDS (0.38) | KDM4EHPGDSCCNA2CDK2CCNA1 | |
| SCHEMBL19670389 | 0.79 | ROCK2 (0.35) | EGFRTRPV3 | |
| SCHEMBL19670258 | 0.79 | KCNH2 (0.37) | ALDH1A1ADORA2AUSP2 | |
| SCHEMBL19706106 | 0.78 | CA2 (0.36) | ADORA2ATRPV3KMO | |
| SCHEMBL16775859 | 0.78 | RPS6KA2 (0.33) | EGFRPIK3CAADORA3ADORA2ACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |