Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670220 | 0.88 | ROCK2 (0.34) | ROCK2BRD4CREBBPPRKG1 | |
| SCHEMBL19670234 | 0.86 | FGFR4 (0.35) | PRMT5WDR77CARM1BRD4 | |
| SCHEMBL19670236 | 0.86 | DHODH (0.40) | ROCK2DYRK1A | |
| SCHEMBL17618464 | 0.86 | PRMT5 (0.38) | PRMT5WDR77ROCK2DYRK1APRKG1 | |
| SCHEMBL19670156 | 0.85 | PRMT5 (0.40) | PRMT5WDR77CARM1DYRK1ACYP1A2 | |
| SCHEMBL19670588 | 0.82 | FGFR4 (0.38) | PRMT5WDR77CARM1 | |
| SCHEMBL19670155 | 0.82 | HDAC2 (0.36) | ROCK2BRD4 | |
| SCHEMBL19670423 | 0.82 | TRPV3 (0.38) | ROCK2BRD4CREBBPPRKG1 | |
| SCHEMBL19670377 | 0.79 | CRACR2A (0.35) | BRD4CREBBP | |
| SCHEMBL19365513 | 0.77 | PRMT5 (0.41) | PRMT5WDR77CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |