Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670156 | 0.89 | PRMT5 (0.40) | CARM1CYP3A4CYP2C9PRMT5WDR77 | |
| SCHEMBL19669050 | 0.89 | TRPV1 (0.35) | FGFR4BRD4 | |
| SCHEMBL19670362 | 0.86 | IRAK4 (0.39) | GAKPDGFRB | |
| SCHEMBL19670379 | 0.86 | PRMT5 (0.37) | CARM1PRMT5WDR77BRD4 | |
| SCHEMBL19670588 | 0.85 | FGFR4 (0.38) | FGFR4CARM1PRMT5WDR77ADRB2 | |
| SCHEMBL17618452 | 0.85 | MAPK14 (0.35) | FGFR4CARM1MAPK14GAKLCK | |
| SCHEMBL19670246 | 0.82 | SCN9A (0.39) | FGFR4MAPT | |
| SCHEMBL19670420 | 0.82 | HDAC2 (0.42) | FGFR4BRD4 | |
| SCHEMBL19670365 | 0.82 | VCP (0.37) | FGFR4GRM5 | |
| SCHEMBL19365594 | 0.82 | RAF1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |