Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670484 | 0.90 | FAAH (0.37) | FGFR4FAAHCSNK1DCSNK1EPDK1 | |
| SCHEMBL19670156 | 0.87 | PRMT5 (0.40) | CARM1PRMT5ADRB2ADRB1ADRB3 | |
| SCHEMBL17618465 | 0.86 | FAAH (0.38) | FGFR4FAAHCARM1PRMT5TSHR | |
| SCHEMBL19670373 | 0.86 | KDR (0.41) | FGFR4FAAHMAPK1CSNK1DCSNK1E | |
| SCHEMBL19670234 | 0.85 | FGFR4 (0.35) | FGFR4CARM1PRMT5ADRB2ADRB1 | |
| SCHEMBL19670233 | 0.83 | FAAH (0.39) | FGFR4FAAHTSHRMAPK1USP30 | |
| SCHEMBL19670584 | 0.83 | FAAH (0.41) | FGFR4FAAHTSHRCSNK1DCSNK1E | |
| SCHEMBL19670379 | 0.82 | PRMT5 (0.37) | CARM1PRMT5WDR77 | |
| SCHEMBL19670266 | 0.81 | FGFR4 (0.41) | FGFR4FAAHTSHRMAPK1CSNK1D | |
| SCHEMBL19365394 | 0.81 | FAAH (0.39) | FGFR4FAAHUSP30CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |