Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670379 | 0.86 | PRMT5 (0.37) | DYRK1AROCK2 | |
| SCHEMBL16775950 | 0.86 | SLC5A1 (0.40) | DHODHIRAK4SLC5A1DYRK1AFYN | |
| SCHEMBL19670423 | 0.85 | TRPV3 (0.38) | TEKTRPV3ROCK2 | |
| SCHEMBL19670155 | 0.85 | HDAC2 (0.36) | TEKROCK2 | |
| SCHEMBL19670362 | 0.84 | IRAK4 (0.39) | IRAK4SLC5A1SCN9AFYNTYRO3 | |
| SCHEMBL17618462 | 0.84 | ABL1 (0.41) | DHODHIRAK4HTR2CDYRK1A | |
| SCHEMBL19670150 | 0.84 | IRAK4 (0.40) | IRAK4SLC5A1HTR2CSCN9AFYN | |
| SCHEMBL19670377 | 0.84 | CRACR2A (0.35) | TRPV3 | |
| SCHEMBL19365522 | 0.83 | KDM4E (0.39) | IRAK4SLC5A1HTR2CDYRK1AFYN | |
| SCHEMBL19670168 | 0.83 | IRAK4 (0.43) | IRAK4SLC5A1SCN9AFYNTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |