Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365445 | 0.86 | TRPM8 (0.43) | TRPV1ARPTGS1PTGS2TRPM8 | |
| SCHEMBL19670368 | 0.85 | FGFR4 (0.39) | TRPV1PIK3C3 | |
| SCHEMBL19365613 | 0.85 | FAAH (0.40) | TRPV1PTGS1PTGS2 | |
| SCHEMBL19670375 | 0.84 | TRPV1 (0.41) | TRPV1ARPTGS1PTGS2SCN9A | |
| SCHEMBL19670232 | 0.84 | PIM2 (0.43) | TRPV1PIM1PIM3PIM2 | |
| SCHEMBL17618443 | 0.82 | TRPV1 (0.49) | TRPV1ARPTGS1PTGS2KMO | |
| SCHEMBL19365426 | 0.81 | GSK3B (0.41) | TRPV1PTGS1PTGS2 | |
| SCHEMBL19365370 | 0.81 | PTGS1 (0.41) | TRPV1PTGS1PTGS2 | |
| SCHEMBL19670150 | 0.81 | IRAK4 (0.40) | TRPV1PIM1PIM3PIM2SCN9A | |
| SCHEMBL19365317 | 0.80 | GSK3B (0.39) | TRPV1PTGS1PTGS2PIM2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |