Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670374 | 0.85 | TRPV1 (0.48) | TRPV1PIK3C3 | |
| SCHEMBL17618448 | 0.85 | FAAH (0.40) | FGFR4MPLFAAHCYP1A2TSHR | |
| SCHEMBL19670149 | 0.84 | FGFR4 (0.39) | FGFR4FAAHKIT | |
| SCHEMBL19670373 | 0.83 | KDR (0.41) | FGFR4FAAHKDM4EHSD17B10MAPK1 | |
| SCHEMBL19365299 | 0.81 | FGFR4 (0.40) | FGFR4FAAHKDM4EMAPK1ALDH1A1 | |
| SCHEMBL19670267 | 0.81 | FGFR4 (0.41) | FGFR4FAAHKDM4EALDH1A1HTT | |
| SCHEMBL19670266 | 0.81 | FGFR4 (0.41) | FGFR4FAAHTSHRTP53MAPK1 | |
| SCHEMBL19670233 | 0.80 | FAAH (0.39) | FGFR4FAAHCYP1A2TSHRCYP2C19 | |
| SCHEMBL19670584 | 0.80 | FAAH (0.41) | FGFR4FAAHTSHRCYP2C19CYP3A4 | |
| SCHEMBL19365442 | 0.80 | FAAH (0.37) | FGFR4FAAHKDM4EHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |