Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 6/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670150 | 0.89 | IRAK4 (0.40) | IRAK4SCN9ASLC5A1FYNPIM1 | |
| SCHEMBL19670246 | 0.89 | SCN9A (0.39) | SCN9AFYNHCRTR1 | |
| SCHEMBL19670234 | 0.86 | FGFR4 (0.35) | GAKPDGFRB | |
| SCHEMBL19670168 | 0.86 | IRAK4 (0.43) | IRAK4SCN9ASLC5A1FYNPIM1 | |
| SCHEMBL19670373 | 0.85 | KDR (0.41) | IRAK4SCN9ASLC5A1FYN | |
| SCHEMBL19365522 | 0.85 | KDM4E (0.39) | IRAK4SLC5A1FYNTYRO3 | |
| SCHEMBL19670365 | 0.85 | VCP (0.37) | HCRTR1 | |
| SCHEMBL19670420 | 0.85 | HDAC2 (0.42) | — | |
| SCHEMBL19670236 | 0.84 | DHODH (0.40) | IRAK4SCN9ASLC5A1FYNTYRO3 | |
| SCHEMBL17618440 | 0.84 | ABL1 (0.40) | IRAK4SLC5A1FYNPIM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |