Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 3/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 9/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365596 | 0.88 | ADORA2A (0.39) | FYNPIM1PIM2FLT3KCNH2 | |
| SCHEMBL19670150 | 0.88 | IRAK4 (0.40) | IRAK4FYNPIM1PIM2FLT3 | |
| SCHEMBL19670362 | 0.86 | IRAK4 (0.39) | IRAK4FYNPIM1PIM2FLT3 | |
| SCHEMBL19670228 | 0.86 | NPC1 (0.38) | — | |
| SCHEMBL17618478 | 0.85 | IRAK4 (0.42) | IRAK4SCDFYNPIM1PIM2 | |
| SCHEMBL19670373 | 0.85 | KDR (0.41) | IRAK4FYNSLC5A1GSK3BMAPK14 | |
| SCHEMBL19365522 | 0.85 | KDM4E (0.39) | IRAK4FYNSLC5A1TYRO3 | |
| SCHEMBL19670236 | 0.83 | DHODH (0.40) | IRAK4FYNSLC5A1TYRO3SCN9A | |
| SCHEMBL19670590 | 0.78 | IRAK4 (0.41) | IRAK4FYNPIM1PIM2KCNH2 | |
| SCHEMBL19670428 | 0.77 | ABL1 (0.40) | IRAK4FYNPIM1PIM2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |