Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 7/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670373 | 0.88 | KDR (0.41) | KDM4EHPGDMAPK1HSD17B10IRAK4 | |
| SCHEMBL19670471 | 0.86 | POLQ (0.35) | IRAK4DYRK1ABRAFNEK2EGFR | |
| SCHEMBL17618494 | 0.85 | HPGDS (0.39) | KDM4EHPGDMAPK1HSD17B10IRAK4 | |
| SCHEMBL19365517 | 0.85 | BRAF (0.40) | DYRK1ABRAF | |
| SCHEMBL19670362 | 0.85 | IRAK4 (0.39) | IRAK4SLC5A1FYNTYRO3 | |
| SCHEMBL19670168 | 0.85 | IRAK4 (0.43) | IRAK4SLC5A1FYNTYRO3 | |
| SCHEMBL19670150 | 0.85 | IRAK4 (0.40) | IRAK4HTR2CSLC5A1FYNTYRO3 | |
| SCHEMBL19670236 | 0.83 | DHODH (0.40) | IRAK4HTR2CSLC5A1DYRK1ACYP2D6 | |
| SCHEMBL19670515 | 0.83 | WNT3A (0.35) | MAPK1HPGDS | |
| SCHEMBL19670428 | 0.79 | ABL1 (0.40) | IRAK4HTR2CSLC5A1HPGDSDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |