Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | MTOR | P42345 | 4/20 | 0.34 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670266 | 0.90 | FGFR4 (0.41) | FGFR4FAAHABL1PDK1PDK2 | |
| SCHEMBL19365658 | 0.87 | FGFR4 (0.40) | FGFR4FAAHABL1PDK1PDK2 | |
| SCHEMBL19365299 | 0.86 | FGFR4 (0.40) | FGFR4FAAHPDK1PDK2PDK3 | |
| SCHEMBL19364889 | 0.85 | FGFR4 (0.49) | FGFR4FAAHABL1KCNH2CYP2C9 | |
| SCHEMBL17618525 | 0.85 | FAAH (0.40) | FGFR4FAAHABL1KCNH2CYP2C9 | |
| SCHEMBL16776032 | 0.84 | KCNH2 (0.41) | FGFR4FAAHABL1PDK1PDK2 | |
| SCHEMBL19670584 | 0.84 | FAAH (0.41) | FGFR4FAAHABL1PDK1PDK2 | |
| SCHEMBL19670149 | 0.84 | FGFR4 (0.39) | FGFR4FAAHPDK1PDK2PDK3 | |
| SCHEMBL19670233 | 0.84 | FAAH (0.39) | FGFR4FAAHPDK1PDK2PDK3 | |
| SCHEMBL19365394 | 0.83 | FAAH (0.39) | FGFR4FAAHPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |