Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 9/20 | 0.35 |
| ▸ | AKT1 | P31749 | 8/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365299 | 0.90 | FGFR4 (0.40) | FGFR4HPGDSFAAHAKT1PDK1 | |
| SCHEMBL19670266 | 0.89 | FGFR4 (0.41) | FGFR4HPGDSFAAHPDK1PDK2 | |
| SCHEMBL19670444 | 0.86 | ITGB2 (0.36) | FGFR4HPGDSFAAHPDK1PDK2 | |
| SCHEMBL19365725 | 0.85 | FGFR4 (0.37) | FGFR4HPGDSFAAHPDK1PDK2 | |
| SCHEMBL19365721 | 0.85 | FGFR4 (0.37) | FGFR4HPGDSFAAHPDK1PDK2 | |
| SCHEMBL19670375 | 0.85 | TRPV1 (0.41) | GSK3BKIT | |
| SCHEMBL19670373 | 0.85 | KDR (0.41) | FGFR4HPGDSFAAHCSNK1DCSNK1E | |
| SCHEMBL17618449 | 0.85 | HPGDS (0.38) | FGFR4HPGDSFAAHRPS6KB1AKT1 | |
| SCHEMBL19670368 | 0.84 | FGFR4 (0.39) | FGFR4FAAHKIT | |
| SCHEMBL19670334 | 0.84 | FGFR4 (0.36) | FGFR4HPGDSFAAHPDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |