Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 6/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | DLK1 | P80370 | 2/20 | 0.32 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365725 | 0.88 | FGFR4 (0.37) | FGFR4FAAHHPGDSPDK1PDK2 | |
| SCHEMBL19365721 | 0.88 | FGFR4 (0.37) | FGFR4FAAHHPGDSPDK1PDK2 | |
| SCHEMBL19361177 | 0.87 | MAP3K12 (0.37) | FGFR4MAP3K12FAAHCACNA1HSCN10A | |
| SCHEMBL19670226 | 0.87 | CNR2 (0.38) | MAP3K12WNT1GSK3BDYRK1ADLK1 | |
| SCHEMBL19670360 | 0.86 | KARS1 (0.40) | MAP3K12WNT1GSK3BDYRK1ADLK1 | |
| SCHEMBL19670356 | 0.86 | MAP3K12 (0.34) | MAP3K12FAAHCACNA1HWNT1GSK3B | |
| SCHEMBL19670444 | 0.86 | ITGB2 (0.36) | FGFR4MAP3K12FAAHHPGDSPDK1 | |
| SCHEMBL19365299 | 0.86 | FGFR4 (0.40) | FGFR4FAAHGSK3BHPGDSPDK1 | |
| SCHEMBL19670266 | 0.85 | FGFR4 (0.41) | FGFR4FAAHGSK3BHPGDSPDK1 | |
| SCHEMBL19670149 | 0.84 | FGFR4 (0.39) | FGFR4FAAHGSK3BHPGDSPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |