Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 10/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20733178 | 0.89 | MAPK1 (0.35) | PIM1ROCK2ROCK1CDC42BPBALDH1A1 | |
| SCHEMBL19670633 | 0.88 | WNT3A (0.34) | PIM1MAPK1 | |
| SCHEMBL19706212 | 0.85 | HRH3 (0.34) | PIM1ROCK2ROCK1MAPTGRM5 | |
| SCHEMBL19670538 | 0.84 | ROCK1 (0.34) | ROCK2ROCK1CDC42BPBCDC42BPAMAPK1 | |
| SCHEMBL20733313 | 0.82 | MAPK1 (0.34) | GRM5MAPK1 | |
| SCHEMBL16776482 | 0.82 | ALDH1A1 (0.42) | PIM1ALDH1A1MAPTGRM5PIM3 | |
| SCHEMBL19706731 | 0.80 | OGA (0.39) | PIM1MAPK1 | |
| SCHEMBL19670481 | 0.80 | KARS1 (0.41) | ALDH1A1MAPTMAPK1 | |
| SCHEMBL19670625 | 0.80 | HRH3 (0.33) | MAPK1 | |
| SCHEMBL19706138 | 0.78 | WNT3A (0.33) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |