Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 5/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670625 | 0.88 | HRH3 (0.33) | KARS1HRH3MAPK1TGFBR1 | |
| SCHEMBL19670633 | 0.87 | WNT3A (0.34) | HRH3MAPK1PRKD1 | |
| SCHEMBL19706212 | 0.86 | HRH3 (0.34) | KARS1HRH3MAPTMAPK1PRKD1 | |
| SCHEMBL19706138 | 0.85 | WNT3A (0.33) | HRH3MAPK1TGFBR1 | |
| SCHEMBL19670538 | 0.85 | ROCK1 (0.34) | HRH3MAPK1 | |
| SCHEMBL19706928 | 0.85 | HRH3 (0.33) | HRH3MAPK1 | |
| SCHEMBL19670504 | 0.83 | MAPK1 (0.32) | HRH3MAPK1 | |
| SCHEMBL19706215 | 0.82 | MAP4K4 (0.34) | — | |
| SCHEMBL17778323 | 0.81 | KARS1 (0.40) | KARS1MAP3K12SYKKDM4EALDH1A1 | |
| SCHEMBL16754282 | 0.81 | KARS1 (0.40) | KARS1MAP3K12SYKKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |