Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.31 |
| ▸ | IDH1 | O75874 | 2/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.30 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670481 | 0.88 | KARS1 (0.41) | HRH3TGFBR1KARS1MAPK1 | |
| SCHEMBL19670633 | 0.87 | WNT3A (0.34) | HRH3SCDMAP4K4MAPK1 | |
| SCHEMBL19706928 | 0.85 | HRH3 (0.33) | HRH3SCDMAP4K4USP30MAPK1 | |
| SCHEMBL19670538 | 0.85 | ROCK1 (0.34) | HRH3MAP4K4USP30MAPK1CARM1 | |
| SCHEMBL19706212 | 0.84 | HRH3 (0.34) | HRH3MAP4K4KARS1MAPK1CARM1 | |
| SCHEMBL19706138 | 0.84 | WNT3A (0.33) | HRH3TGFBR1MAPK1 | |
| SCHEMBL19670504 | 0.83 | MAPK1 (0.32) | HRH3USP30MAPK1 | |
| SCHEMBL19706215 | 0.82 | MAP4K4 (0.34) | MAP4K4USP30 | |
| SCHEMBL17778384 | 0.80 | L3MBTL1 (0.35) | MAP4K4USP30 | |
| SCHEMBL16754615 | 0.80 | L3MBTL1 (0.35) | MAP4K4USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |