Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 4/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670663 | 0.90 | FGFR4 (0.40) | FAAHGRIN2BFGFR4TRPV3PDE4B | |
| SCHEMBL19670433 | 0.89 | ALOX15 (0.36) | GRIN2BFGFR4RPS6KB1TRPV3PDE4B | |
| SCHEMBL19670569 | 0.89 | FAAH (0.36) | FAAHMPLRPS6KA2 | |
| SCHEMBL19670453 | 0.88 | HTR2C (0.36) | GRIN2BRPS6KB1AKT1TRPV3PDE4B | |
| SCHEMBL19670530 | 0.87 | FAAH (0.41) | FAAHGRIN2BRPS6KB1AKT1TRPV3 | |
| SCHEMBL19670692 | 0.84 | BRAF (0.38) | TRPV3PDE4BBRAF | |
| SCHEMBL12654526 | 0.84 | MPL (0.42) | FAAHMPL | |
| SCHEMBL19670591 | 0.78 | FGFR4 (0.42) | FAAHFGFR4 | |
| SCHEMBL19365327 | 0.77 | FAAH (0.36) | FAAHFGFR4MPLRPS6KA2 | |
| SCHEMBL19670124 | 0.77 | WNT3A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |