Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.38 |
| ▸ | HTR2A | P28223 | 6/20 | 0.36 |
| ▸ | HTR2C | P28335 | 6/20 | 0.36 |
| ▸ | HTR2B | P41595 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 10/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670453 | 0.91 | HTR2C (0.36) | BRAFHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL19670565 | 0.90 | WNT3A (0.37) | BRAFHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL19670433 | 0.86 | ALOX15 (0.36) | BRAFTRPV3RAF1PDE4B | |
| SCHEMBL19699073 | 0.85 | HTR2C (0.39) | HTR2AHTR2CHTR2BCYP1A2TRPV3 | |
| SCHEMBL19670394 | 0.84 | FAAH (0.34) | BRAFTRPV3PDE4B | |
| SCHEMBL19670663 | 0.83 | FGFR4 (0.40) | HTR2AHTR2CCYP1A2TRPV3PDE4B | |
| SCHEMBL19670530 | 0.82 | FAAH (0.41) | HTR2AHTR2CHTR2BTRPV3PDE4B | |
| SCHEMBL19706092 | 0.81 | CYP11B2 (0.37) | HTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL19670620 | 0.80 | HTR2A (0.38) | HTR2AHTR2C | |
| SCHEMBL19670352 | 0.79 | HTR2C (0.47) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |