Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618407 | 0.83 | KIT (0.41) | CHRM2JAK2TYK2KITCTSA | |
| SCHEMBL19670221 | 0.83 | UBE2M (0.37) | CTSAKDM1ARAF1BRAF | |
| SCHEMBL19670214 | 0.83 | TRPA1 (0.38) | JAK2CHRM1KITKDM1AMAOA | |
| SCHEMBL19670135 | 0.83 | MEN1 (0.41) | CHRM1KDM1AMAOAMAOBCA2 | |
| SCHEMBL19670179 | 0.82 | HTR2C (0.46) | KITMAPK14BRAFTRPV1 | |
| SCHEMBL19670141 | 0.82 | SCN9A (0.37) | CHRM2CHRM1KDM1AMAOAMAOB | |
| SCHEMBL19670412 | 0.81 | POLB (0.37) | CHRM2JAK2CHRM1KITKDM1A | |
| SCHEMBL19670209 | 0.81 | CNR2 (0.36) | JAK2CHRM1CTSAKDM1AMAOA | |
| SCHEMBL19670644 | 0.81 | HSD17B10 (0.37) | CHRM1KDM1AMAOAMAOBCA2 | |
| SCHEMBL19670425 | 0.81 | KMT2A (0.39) | CHRM1KDM1AMAOAMAOBCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |