Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670214 | 0.86 | TRPA1 (0.38) | CHRM3ALDH1A1LMNACHRM1MEN1 | |
| SCHEMBL19670580 | 0.86 | TRPV1 (0.43) | SCN9ACHRM3MCHR1TRPV1MEN1 | |
| SCHEMBL19670412 | 0.86 | POLB (0.37) | CHRM3MCHR1ALDH1A1POLBHSD17B10 | |
| SCHEMBL19670218 | 0.85 | MAPT (0.43) | MCHR1KDM4EALDH1A1TSHRTRPV1 | |
| SCHEMBL19670410 | 0.85 | TRPV1 (0.43) | CHRM3HDAC1MCHR1TP53TRPV1 | |
| SCHEMBL19670215 | 0.84 | CNR2 (0.41) | — | |
| SCHEMBL19670209 | 0.84 | CNR2 (0.36) | CHRM3LMNACHRM1MEN1UBE2M | |
| SCHEMBL19670221 | 0.83 | UBE2M (0.37) | ALDH1A1TP53POLBMEN1UBE2M | |
| SCHEMBL19670579 | 0.83 | TRPA1 (0.36) | CHRM3TRPV1CHRM1MEN1UBE2M | |
| SCHEMBL19670179 | 0.83 | HTR2C (0.46) | TSHRTRPV1MEN1UBE2MKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |