Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670141 | 0.86 | SCN9A (0.37) | POLBADORA2AKDM1AALDH1A1MCHR1 | |
| SCHEMBL19670214 | 0.85 | TRPA1 (0.38) | ADORA2AKDM1AKITMAPTRAF1 | |
| SCHEMBL19670218 | 0.85 | MAPT (0.43) | ADORA2AKDM1AMAPTRAF1BRAF | |
| SCHEMBL19670221 | 0.84 | UBE2M (0.37) | POLBADORA2AKDM1AMAPTRAF1 | |
| SCHEMBL19670580 | 0.84 | TRPV1 (0.43) | KDM1ACSF1RMCHR1MEN1KMT2A | |
| SCHEMBL19670135 | 0.84 | MEN1 (0.41) | ADORA2AKDM1AMAPTRAF1BRAF | |
| SCHEMBL19670209 | 0.83 | CNR2 (0.36) | ADORA2AKDM1AMAPTRAF1BRAF | |
| SCHEMBL19670410 | 0.83 | TRPV1 (0.43) | ADORA2AKDM1AMAPTMCHR1MEN1 | |
| SCHEMBL19670425 | 0.83 | KMT2A (0.39) | ADORA2AKDM1AMAPTRAF1BRAF | |
| SCHEMBL19670579 | 0.83 | TRPA1 (0.36) | ADORA2AKDM1ARAF1BRAFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |