Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.35 |
| ▸ | GSK3B | P49841 | 4/20 | 0.35 |
| ▸ | WNT1 | P04628 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365558 | 0.89 | KDR (0.40) | KMOBRAFPIK3CDPIK3CAPIK3CG | |
| SCHEMBL19670424 | 0.83 | MAPK14 (0.37) | KMOBRAFPIK3CDPIK3CAPIK3CG | |
| SCHEMBL19365786 | 0.83 | RHOA (0.37) | KMOBRAFPIK3CDPIK3CAPIK3CG | |
| SCHEMBL19670403 | 0.82 | BRAF (0.39) | BRAFPIK3CDPIK3CAPIK3CGRHOA | |
| SCHEMBL19670289 | 0.77 | BRAF (0.42) | KMOBRAFPIK3CDPIK3CAPIK3CG | |
| SCHEMBL19365806 | 0.73 | RHOA (0.42) | KMOBRAFPIK3CDPIK3CAPIK3CG | |
| SCHEMBL19706034 | 0.73 | ALDH1A1 (0.39) | KMOPIK3CDPIK3CAPIK3CGTSHR | |
| SCHEMBL19670450 | 0.73 | MEN1 (0.41) | PIK3CDPIK3CAPIK3CGCA2CA9 | |
| SCHEMBL19365833 | 0.73 | RHOA (0.43) | BRAFPIK3CDPIK3CAPIK3CGRHOA | |
| SCHEMBL19670382 | 0.73 | NPY5R (0.42) | BRAFPIK3CDPIK3CAPIK3CGCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |