Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365412 | 1.00 | EGFR (0.40) | EGFRCNR2AVPR1BMTORDRD2 | |
| SCHEMBL19670465 | 0.86 | CNR2 (0.35) | CNR2DRD2DRD4DRD3GSK3B | |
| SCHEMBL17618583 | 0.86 | EGFR (0.41) | EGFRCNR2AVPR1BDRD2DRD4 | |
| SCHEMBL19365561 | 0.84 | TRPM8 (0.38) | CNR2GSK3BDYRK1AMEN1HTT | |
| SCHEMBL19365554 | 0.84 | TRPM8 (0.38) | CNR2GSK3BDYRK1AMEN1HTT | |
| SCHEMBL19365410 | 0.82 | RAB9A (0.41) | CNR2DRD4GSK3BDYRK1AMEN1 | |
| SCHEMBL19365409 | 0.82 | RAB9A (0.41) | CNR2DRD4GSK3BDYRK1AMEN1 | |
| SCHEMBL19670441 | 0.82 | GRM5 (0.38) | MTORGSK3BDYRK1AMEN1HTT | |
| SCHEMBL19364814 | 0.82 | GRM5 (0.38) | MTORGSK3BDYRK1AMEN1HTT | |
| SCHEMBL19365553 | 0.81 | CNR2 (0.42) | CNR2DRD2DRD4DRD3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |